In healthy individuals, immune checkpoint molecules prevent autoimmune responses and limit immune cell-mediated tissue damage.Tumors frequently exploit these tokidoki x sanrio blind box molecules to evade eradication by the immune system.Over the past years, immune checkpoint blockade of cytotoxic T lymphocyte antigen-4 (CTLA-4) and programmed death-1 (PD-1) emerged as promising strategies to activate anti-tumor cytotoxic T cell responses.
Although complete regression and long-term survival climax blueberry cross pollination is achieved in some patients, not all patients respond.This review describes promising, novel combination approaches involving immune checkpoint blockade, aimed at increasing response-rates to the single treatments.